Disque Hall 919
- Current Students
Physics Colloquium: "Probing the Principles of Protein Aggregation"
Thursday, May 9, 2013
3:30 PM-4:30 PM
Speaker: Dr. John Straub, Boston University
Aggregation of proteins of known sequence is linked to Alzheimer's disease and other neurodegenerative disorders. As a result of evidence suggesting that soluble low molecular weight (LMW) aggregates of amyloidogenic proteins are the primary cause of neurotoxicity, it has become urgent to understand the molecular mechanisms of formation of LMW oligomers. We will report on our efforts to probe the early events leading to oligomer formation through the use of molecular dynamics simulations. In particular, we will explore the effects of sequence variation on the “aggregation pathway” and identify the key interactions essential to oligomer formation, and the mechanism of fibril growth.
Host: Dr. Brigita Urbanc
Dr. Brigita Urbanc