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Alisa Morss Clyne

Associate Professor

Dr. Alisa Morss-Clyne

Office: Alumni Engineering Labs (AEL) 170C
Phone: 215-895-2366
Fax: 215-895-1478
Email: asm67@drexel.edu

Website:

 Vascular Kinetics Laboratory at Drexel University


Specialization:

Cardiovascular Biomechanics; Tissue Engineering; Drug Delivery; Angiogenesis in Diabetes.


CV

CV for Alisa Morss Clyne [PDF]

Research Interests

Microfluidic devices to measure cell biochemical and mechanical responses; Auto-fluorescent mechanosensors; Flow and strain effects on endothelial cell – basement membrane interaction; Endothelial cell – smooth muscle cell interactions in diabetes; Plasma angiogenesis; advanced materials for accelerated wound healing; Nanoparticles for cardiovascular disease; sickle cell interactions with the vascular wall

Biography

Alisa Morss Clyne is an Associate Professor in the Mechanical Engineering and Mechanics Department and the principal investigator of the Vascular Kinetics Laboratory.  She received a B.S. in Mechanical Engineering from Stanford University in 1996, a M.S. in Mechanical Engineering from the University of Cincinnati in 1999 and her PhD in Medical and Mechanical Engineering from Harvard-MIT Division of Health Sciences and Technology in 2006.

She currently serves as the Assistant Dean for Undergraduate Affairs for the College of Engineering.


Professional Societies

AAAS,
American Society for Biochemistry and Molecular Biology,
Biomedical Engineering Society,
American Society of Mechanical Engineers,
Sigma Xi,
Society of Women Engineers,
IEEE Engineering in Medicine and Biology Society,
North American Vascular Biology Organization

Academic Distinctions

2011 BMES-SPRBM Rising Star Award
2009 Louis and Bessie Stein Fellow
2008 National Science Foundation CAREER Award

Publications

Kemeny S, Figueroa D, Morss Clyne A. Both low and high glucose inhibit endothelial cell
response to shear stress. (In review)

Patel N, Morss Clyne A. A computational model of fibroblast growth factor-2 binding in fluid flow. (In review)

Arjunan K, Morss Clyne A. A nitric oxide producing pin-to-hole spark discharge plasma enhances endothelial cell proliferation and migration. (In review)

Yu M, Huang S, Yu KJ, Morss Clyne A. (2012) Dextran and polymer polyethylene glycol (PEG) coating reduce both 5 and 30 nm iron oxide nanoparticle cytotoxicity in 2D and 3D cell culture. International Journal of Molecular Sciences 13(5): p. 5554-70.

Arjunan K, Friedman G, Fridman A, Morss Clyne A. (2012) Non-thermal dielectric barrier discharge plasma induces angiogenesis through reactive oxygen species. Journal of the Royal Society Interface 9(66): p. 147-157.

Arjunan K, Morss Clyne A. (2011) Hydroxyl radical and hydrogen peroxide are primarily responsible for dielectric barrier discharge plasma-induced angiogenesis. Plasma Processes and Polymers 8: p. 1154-64.

Kemeny S, Figueroa D, Andrews A, Barbee K, Morss Clyne A. (2011) Glycated collagen alters endothelial cell actin alignment and nitric oxide release in response to fluid shear stress. Journal of Biomechanics 44 (10): p. 1927-35.

Figueroa D, Kemeny S, Morss Clyne A. (2011) Glycated collagen impairs endothelial cell response to cyclic stretch. Cellular and Molecular Bioengineering 4 (2): p. 220-30.

Kemeny S, Morss Clyne A. (2011) A simplified implementation of edge detection in MATLAB is faster and more sensitive than Fast Fourier Transform for actin fiber alignment quantification. Microscopy and Microanalysis 17: p. 156-166.

Dobrynin D, Arjunan KP, Fridman A, Friedman G, Morss Clyne A. (2011) Direct and controllable nitric oxide delivery into biological media and living cells by a pin-to-hole spark discharge (PHD) plasma. Journal of Physics D: Applied Physics 44: 075201.

Buyukhatipoglu K, Morss Clyne A.(2011) Superparamagnetic iron oxide nanoparticles change endothelial cell morphology and mechanics via reactive oxygen species formation. Journal of Biomedical Materials Research Part A 96A (1): p. 186-195.

Morss Clyne A. Thermal processing of tissue engineering scaffolds. (2011) ASME Journal of
Heat Transfer Special Issue on Advanced Thermal Processing 133(3): 034001. 

 


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