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Sergey Markin

Sergey Markin, PhD

Research Assistant Professor


Department: Neurobiology & Anatomy

Education

  • PhD in Computer Science - Rostov State University (1997)
  • MS in Radiophysics - Rostove State University (1992)

Dr. Markin is a research assistant professor in the Department of Neurobiology & Anatomy at Drexel University College of Medicine.

Research Interests

Computational neuroscience, motor control, modeling neural control of respiration and locomotion

Research

Dr. Markin earned his PhD while working as a junior researcher in the Laboratory for Neuroinformatics of Sensory and Motor Systems at A. B. Kogan Research Institute for Neurocybernetics, Rostov State University in 1997. From 1998 to 1999, he was a visiting scientist in the Center for Artificial Vision Research, Seoul National University in Korea.

He came to Drexel in 2000. Until 2002 he held a research scholar position in the laboratory of Dr. Simon Giszter at the Department of Neurobiology and Anatomy. Later, from 2002 ot 2004 he held a research associate position in the laboratory of Dr. Ilya Rybak at Drexel University School of Biomedical Engineering. Dr. Markin was also a visiting scientist in the Spinal Cord Research Center at the University of Manitoba in Winnipeg, Canada. In 2006, Markin joined the Department of Neurobiology and Anatomy at Drexel University College of Medicine as a research assistant professor.

Dr. Markin's research interests include:

  • Computational modeling of biological neurons and neural networks
  • Kinetics of ionic channels and their role in the neuronal pattern formation cross-level integration of subcellular, cellular, network and systems brain/neural mechanisms
  • Spatiotemporal dynamics of activity and oscillations in biological neural networks
  • Designing computational tools for the modeling of biological neural networks
  • Designing computational tools for the processing and analysis of experimental data

Motor control (general issues):

  • Neural control of voluntary and automatic movements
  • Neurogenesis of the locomotor rhythm and neural control of locomotion
  • Neurogenesis of the respiratory rhythm and neural control of breathing

Neurogenesis of the locomotor rhythm and neural control of locomotion:

  • Cellular and network mechanisms for locomotor rhythm generation in mammalian spinal cord
  • Afferent and supra-spinal control of the spinal central pattern generator (CPG) during walking
  • Applications to restoration of the locomotor function after spinal cord injuries and diseases

Neurogenesis of the respiratory rhythm and neural control of breathing:

  • Network mechanisms for rhythm generation and pattern formation in the respiratory brainstem
  • Spatial organization of the brainstem respiratory center
  • The role of and interaction between cellular (e.g., ionic channels, pacemaker properties) and network mechanisms in the respiratory rhythm and pattern generation

Dr. Markin is an investigator in two major project supported by the NINDS/NIH:

  • A Bioengineering Research Partnership (BRP) project, "Spinal control of locomotion: studies and applications"
  • A Collaborative Research in Computational NeuroScience (CRCNS) project, "State-dependent neural mechanisms for respiratory pattern generation"

Publications

“A neuromechanical model of spinal control of locomotion”
Markin SN, Klishko AN, Shevtsova NA, Lemay MA, Prilutsky BI, and Rybak IA
Neuromechanical Modeling of Posture and Locomotion
(Prilutsky, BI, and Edwards, D. H., eds.). Springer, New York. pp. 21-65, 2016.

“Modeling the organization of spinal cord neural circuits controlling two-joint muscles”
Shevtsova NA, Hamade K, Chakrabarty S, Markin SN, Prilutsky BI, and Rybak IA
Neuromechanical Modeling of Posture and Locomotion
(Prilutsky, BI, and Edwards, D. H., eds.). Springer, New York. pp 121-162, 2016

“Organization of left-right coordination of neuronal activity in the mammalian spinal cord: insights from computational modelling”
Shevtsova NA, Talpalar AE, Markin SN, Harris-Warrick RM, Kiehn O, and Rybak IA
J. of Physiology
593:2403-2426. PMCID: PMC4461406, 2015

“A neuromechanical computational model of spinal control of locomotion”
Markin SN
, Klishko AN, Shevtsova NA, Lemay MA, Prilutsky BI, Rybak IA
BMC Neuroscience
, 13(1):48, 2012

“Motoneuronal and muscle synergies involved in cat hindlimb control during fictive and real locomotion: a comparison study”
Markin SN, Lemay MA, Prilutsky BI, and Rybak IA
J. Neurophysiol.
107: 2057-207, 2012

“A dynamical systems analysis of afferent control in a neuro–mechanical model of locomotion”
Spardy LE, Markin SN, Prilutsky BI, Rybak IA, and Rubin JE
BMC Neuroscience, 11(1):19, 2012

“A dynamical systems analysis of afferent control in a neuromechanical model of locomotion: I. Rhythm generation” Spardy LE, Markin SN, Shevtsova NA, Prilutsky BI, Rybak IA, and Rubin JE J. Neural Eng. 8: 065003 (16 pp), 2011

“A dynamical systems analysis of afferent control in a neuromechanical model of locomotion: II. Phase asymmetry”
Spardy LE, Markin SN, Shevtsova NA, Prilutsky BI, Rybak IA, and Rubin JE
J. Neural Eng.
8: 065004 (19 pp), 2011

“Afferent control of locomotor CPG: Insights from a simple neuro-mechanical model”
Markin SN
, Klishko AN, Shevtsova NA, Lemay MA, Prilutsky BI, and Rybak IA
Ann. NY Acad. Sci.
1198: 21-34, 2010

"Spatial organization and state-dependent mechanisms for respiratory rhythm and pattern generation"
Rybak IA, Abdala, APL, Markin SN, Paton JFR, and Smith JC
Progress in Brain Research, 165: 201-220, 2007.

“A Real-Time System for Small Animal Neurorobotics at Spinal or Cortical Levels”
Giszter SF, Hart CB, Udoekwere UI, Markin SN, and Barbe C
Proc. of the 2nd International IEEE EMBS Conference on Neural Engineering, 450-453, 2005

"Method to Detect Impulses of Various Duration Generated by Purkinje Cells of Cerebellar Cortex"
Markin SN, Podladchikova LN, and Dunin-Barkowski WL
Pattern Recognition and Image Analysis, V. 15, No. 6, 672-675, 2005

“A possible role of the pons in normal respiratory rhythm generation: insights from computational modeling”
Shevtsova NA, Markin SN, Rybak IA
Proc. XIV International Conference on Neurocybernetics, Rostov-on-Don, Russia, Vol. 2, 234-237, 2005

"Generation of respiratory rhythm in a ponto-medullary neural network model"
Shevtsova NA, Markin SN, and Rybak IA
Neurocomputers: development and application 11, 26-40, 2004 (in Russian)

“Fine control of acceleration and force at the cat's toe”
Maltenfort MG, Markin SN, Lemay MA, Giszter SF
Proc. of the 25th Annual International Conference of the IEEE EMBS. Vol. 2, 1734-1737, 2003

"Modeling the spinal cord neural circuitry controlling cat hindlimb movement during locomotion"
Ivashko DG, Prilutsky BI, Markin SN, Chapin JK, and Rybak IA
Neurocomputing 52-54: 621-629, 2002.

“Image preprocessing for identifying the most informative regions in the facial images”
Golovan AV, Shevtsova NA, Podladchikova LN, Markin SN, and Shaposhnikov DG
Pattern Recognition and Image Analysis: Advances in Mathematical Theory and Applications
, Vol. 11, No 2, 313-316, 2001

“Detection of face informative regions by local features”
Golovan AV, Shevtsova NA, Podladchikova LN, Markin SN, Shaposhnikov DG
Neurocomputers: development and application
, 1: 50-57, 2001. (in Russian).

"Activity properties of branches of a climbing fiber which control different Purkinje cells"
Dunin-Barkowski, WL, Markin SN, and Podladchikova LN
Biophysika, 44, 4, 1999 (in Russian

"Estimation of Purkinje cells complex and simple spikes contribution to local field potentials of the cerebellar cortex"
Dunin-Barkowski WL, Markin SN, and Podladchikova LN
Biophysika, 42,2: 516-521, 1997 (in Russian)

“Climbing fiber Purkinje cells twins: A search of extra-rare events in neural systems”
Dunin-Barkowski WL, Markin SN, and Podladchikova LN
Proc. of the 2nd Int. Symp. on Neuroinformatics and Neurocomputers. Rostov-on-Don, Russia
, 100-107, 1995


Contact Information


Research Office

Department of Neurobiology & Anatomy
2900 W. Queen Lane
Philadelphia, PA 19129
Phone: 215.991.8597
Fax: 215.843.9082