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Patrick Loll

Patrick Loll, PhD


Department: Biochemistry & Molecular Biology


  • PhD in Biophysics - John Hopkins University School of Medicine (1989)
  • Postdoctoral training – University of Chicago (1989-1994)

Dr. Loll is a professor in the Department of Biochemistry & Molecular Biology at Drexel University College of Medicine. He is the program director for the Biochemistry MS and PhD programs and course director for the first semester of the Core Curriculum.

Research Overview

Research interests: X-ray crystallography and protein biophysics; integral membrane protein structure; antibiotic resistance; mechanism of anesthetic action; protein homeostasis.


Research in my lab revolves around molecular structure. The underlying goal for all our projects is to understand biologically important processes at the molecular level. Our principal tools are biophysical ones, including in particular X-ray crystallography; we also devote much energy to protein expression and protein biochemistry to support the structural efforts. Specific areas of interest include:

Large natural product antibiotics

We are applying structural, computational, and biophysical methods to deepen our understanding of how antibiotics like vancomycin, ramoplanin, tyrocidine, and bacitracin function. We hope to use this information to design novel drugs to combat antibiotic resistance.

The structural basis of drug action

We are interested in probing the interactions between drugs and their protein targets at the structural level. Currently, we are examining the binding of general anesthetics to model protein targets, with an eye toward elucidating the structural determinants that control anesthetic recognition.

Deubiquitylation by Josephin proteins

Ataxin-3 and other Josephin proteins catalyze the degradation of poly-ubiquitin chains, modulating signals controlling protein breakdown and trafficking. We are using structural and biochemical approaches to study the function of these enzymes.

The structural biology of membrane proteins

Many of the most fascinating and crucial processes which occur in living cells are modulated by integral membrane proteins. Our lab is studying a number of different membrane-bound enzymes, receptors, and transport proteins; in addition, a substantial effort focuses on the development of crystallization methodologies for these molecules.

Research Interests

X-ray crystallography and protein biophysics; integral membrane protein structure; antibiotic resistance; mechanism of anesthetic action; protein homeostasis.


View all of Pat Loll's publications.

"A high resolution crystal structure reveals the molecular details of target recognition by bacitracin."
Economou NJ, Cocklin S, Loll PJ
Proc. Nat. Acad. Sci. USA, 110:14207-14212 (2013)

"The high resolution structure of tyrocidine A reveals an amphipathic dimer."
Loll PJ, Upton EC, Nahoum V, Economou NJ & Cocklin S
Biochim. Biophys. Acta 1838:1199-1207. (2014)

"Membrane proteins, detergents, and crystals: What is the state of the art?"
Loll PJ 
Acta Crystallogr. F70:1576-83 (2014)

"Recognition of Anesthetic Barbiturates by a Protein Binding Site: A High Resolution Structural Analysis."
Oakley S, Vedula SL, Bu W, Meng QC, Xi J, Liu R, Eckenhoff RG & Loll PJ
PLoS One 7: e32070 (2012)

"A carrier protein strategy yields the structure of dalbavancin."
Economou NJ, Nahoum V, Weeks SD, Grasty KC, Zentner IJ, Townsend TM, Bhuiya MW, Cocklin S, Loll PJ
J. Am. Chem. Soc. 134: 4637-4645 (2012)

"Crystal structure of a Josephin-ubiquitin complex: Evolutionary restraints on ataxin-3 deubiquitinating activity."
Weeks SD, Grasty KC, Hernandez-Cuebas L & Loll PJ
J. Biol. Chem. 286, 4555-4565 (2011)

"Vancomycin forms ligand-mediated supramolecular complexes."
Loll PJ, Derhovanessian A, Shapovalov MV, Kaplan J, Yang L, Axelsen PH
J Mol Biol. 385: 200-11 (2009)

"Crystal Structure of Ristocetin A in Complex with a Bacterial Cell Wall Mimetic."
Nahoum V, Spector S & Loll PJ
Acta Crystallogr. D65, 832-838 (2009)

"A unitary anesthetic-binding site at high resolution."
Vedula LS, Brannigan G, Economou NJ, Xi J, Hall MA, Liu R, Rossi MJ, Dailey WP, Grasty KC, Klein ML, Eckenhoff RG & Loll PJ
J. Biol. Chem. 284: 24176-84 (2009)

"A crystal structure of a dimer of the antibiotic ramoplanin illustrates membrane positioning and a potential Lipid II docking interface."
Hamburger JB, Hoertz AJ, Lee A, Senturia RJ, McCafferty DG & Loll PJ
Proc. Nat. Acad. Sci. USA, 106: 13759-64 (Track 2 submission) (2009)

"Crystal structures of Lys-63-linked tri- and di-ubiquitin reveal a highly extended chain architecture."
Weeks SD, Grasty KC, Hernandez-Cuebas L & Loll PJ
Proteins 77: 753-759 (2009)

"Ligation independent cloning vectors for expression of SUMO fusions."
Weeks SD, Drinker M, Loll PJ
Prot. Expr. Purif. 53: 40-50 (2007)

Contact Information

Research Office

Department of Biochemistry & Molecular Biology
245 North 15th Street
Mail Stop 497
Philadelphia, PA 19102
Phone: 215-762-7706
Fax: 215-762-4452