Selected Publications (See all Michael Bouchard's publications in PubMed.)
"A broad investigation of the HBV-mediated changes to primary hepatocyte physiology reveals HBV significantly alters metabolic pathways"
J Lamontagne, JC Casciano, and M Bouchard
Metabolism, Epub ahead of print. PMID: 29410347 (2018)
"The hepatitis B virus HBx proteins elevates cytosolic and mitochondria calcium in cultured human hepatocytes"
JC Casciano and M Bouchard
Virus Research 246: 23-27. PMID: 29307794 (2018)
"Human Liver Sinusoid on a Chip for Hepatitis B Viral Replication Study"
YB Kang, S Rawat, N Duchemin, M Bouchard, and M Noh
Micromachines, 8, 27 (2017)
"Hepatitis B virus modulates store-operated calcium entry to enhance viral replication in primary hepatocytes"
JC Casciano, N Duchemin, RJ Lamontagne, LF Steel, and M Bouchard
PLoSOne, 12(2) PMID: 28151934 (2017)
"Intrinsic hepatocyte dedifferentiation is accompanied by upregulation of mesenchymal markers, protein sialylation and core alpha 1,6 linked fucosylation"
A Mehta, MA Comunale, S Rawat, JC Casciano, J Lamontagne, H Herrera, A Ramanathan, L Betesh, M Wang, P Norton, LF Steel, and M Bouchard
Sci Rep., 6:27965 PMID: 27328854 (2016)
"The Hepatitis B Virus HBx protein activates AKT to simultaneously regulate HBV replication and hepatocyte survival"
S Rawat and M Bouchard
J. Virol.89(2):999-1012 (2015)
"Technical standards for hepatitis B virus X protein(HBx) research"
B Slagle, O Andrisani, M Bouchard, C Lee, J Ou, A Siddiqui
Hepatology, Epub Aug 7 (2014)
"Cell cycle regulation during viral infection"
S Bagga and M Bouchard (2014)
Methods Mol Biol. 1170:165-227 (2014)
"Protein phosphatase 2A (PP2A) regulates low density lipoprotein uptake through regulating sterol response element-binding protein-2 (SREBP-2) DNA binding"
Rice L, M Donigan, M Yang, W Liu, D Pandya, BK Joseph, V Sodi, TL Gearhart, J Yip, M Bouchard, JT Nickels Jr.
J.Biol Chem. 289(24):17268-79 (2014)
"Layered long-term co-culture of hepatocytes and endothelial cells on a transwell membrane: toward engineering the liver sinusoid"
Kang YB, Rawat S, Cirillo J, Bouchard M, Noh HM.
Biofabrication, Dec. 2013; 5(4):045008. doi: 10.1088/1758-5082/5/4/045008. (Epub Nov 26, 2013)
"Modulation of apoptotic signaling by the hepatitis B virus X protein"
Rawat S, A. Clippinger, M. Bouchard
Viruses 8: 2945-72 (2012)
"The hepatitis B virus X protein elevates cytosolic calcium signals by modulating mitochondrial calcium uptake"
B. Yang and M. Bouchard
J Virol. 86: 313-327 (2012)
"The C-terminal region of the hepatitis B virus X protein is essential for its stability and function"
R Lizzano, B Yang, A Clippinger and M Bouchard
Virus Res.155: 231-239 (2011)
"The hepatitis B virus HBx protein modulates cell cycle regulatory proteins in cultured primary human hepatocytes"
T Gearhart and M Bouchard
Virus Res. 155: 363-367 (2011)
"Hepatitis B and C virus hepatocarcinogenesis: lessons learned and future challenges"
M Bouchard and S Navas-Martin
Cancer Letters 305: 123-43 (2011)
"Replication of the hepatitis B virus requires a calcium-dependent HBx-Induced G1 phase arrest of hepatocytes"
T Gearhart and M Bouchard
Virology, 407: 14-25 (2010)
"The hepatitis B virus X protein modulates hepatocyte proliferation pathways to stimulate viral replication"
T Gearhart and M Bouchard
Journal of Virology, 84: 2675-2686 (2010)
"In situ intracellular spectroscopy with surface enhanced raman spectroscopy (SERS)-enabled nanopipettes"
EA Vitol, Z Orynbayeva, M Bouchard, J Azizkhan-Clifford, G Friedman, and Y Gogotsi
ACS Nano, 3; 3529-3536 (2009)
"The hepatitis B virus X protein modulates apoptosis in primary rat hepatocytes by regulating both NF-kB and the mitochondrial permeability transition pore"
A Clippinger, T Gearhart, and M Bouchard
Journal of Virology, 83: 4718-4713 (2009)
"Hepatitis B virus HBx protein localizes to mitochondria in primary rat hepatocytes and modulates mitochondrial membrane potential"
A Clippinger and M Bouchard
Journal of Virology, 82: 6798-6811 (2008)
"Microfluidic platform for hepatitis B viral replication study"
T Sodunke, M Bouchard, and H Noh
Biomed Microdevices, 10: 393-402 (2008)