Teaching Faculty
Professor
Department: Biochemistry & Molecular Biology
Professor
Department: Biochemistry & Molecular Biology
Drexel Engineering/Science Faculty
Department: Chemical and Biological Engineering
Research Interests: Molecular simulations in biophysics and materials, HIV-1 envelope structure and function, protein-ligand binding thermodynamics and kinetics
Department: Physics
Research Interests: Computational studies of confinement effects on the folding of amyloidogenic proteins, spatial correlations of neurons in the brain, firing dynamics of neuronal networks, fluid flow through porous media
Department: Physics
Research Interests: Experimental and theoretical protein dynamics, kinetics of biological self-assembly, including sickle cell and Alzheimer's disease, sickle cell testing and diagnostic devices
Department: Biology
Research Interests: Identifying and characterizing genes involved in pathogenesis of Alzheimer's disease (AD), aiming to identify novel therapeutic strategies to delay or prevent onset of AD
Department: Physics
Research Interests: Computational and experimental biophysics of protein folding and assembly, relevant to Alzheimer's and Parkinson's disease; discrete molecular dynamics of coarse-grained protein and lipid models
Emeritus Faculty
Professor Emerita; Associate Dean for Medical Student Research; Course Director, Cancer Biology
Department: Biochemistry & Molecular Biology
Research Interests: Cellular response to DNA damage, regulation of gene expression, cellular proliferation and the cell cycle
Professor Emerita
Department: Biochemistry & Molecular Biology
Research Interests: Development of curricula (both lecture and problem-based), and of methods to assist and assess student progress through the curricula
Marilyn Jorns, PhD
Professor Emerita
Department: Biochemistry & Molecular Biology
Research Interests: Use of structure-based drug design to develop a new class of drugs to treat heart failure, based on modulation of the gasotransmitter hydrogen sulfide; structure and mechanism of membrane-bound oxidoreductases
Gerald Soslau, PhD
Professor Emeritus
Research Interests: Platelet biochemistry, platelet thrombin receptors
Adjunct Biochemistry Faculty at Fox Chase Cancer Center
Research Interests: Genetic studies to improve screening, early detection and treatment of cancers; mechanisms underlying genetically undefined hereditary cancers; predictive biomarkers for response to chemoradiation therapy; novel strategies to screen for individuals at high risk for cancer
Research Interests: Signal transduction by small G proteins and their effectors and the role of these proteins in regulating cytoskeletal structure, tumor invasion, and metastasis; regulation of insulin signaling
Research Interests: Isolation of primary fibroblasts from various murine and human cancers at different stages of tumorigenesis
Research Interests: Computational structural biology, including homology modeling, fold recognition, molecular dynamics simulations, statistical analysis of the PDB, and bioinformatics
Research Interests: Cancer biology; hepatocellular carcinoma (HCC) initiation; cholangiocarcinoma (CCA) subtypes; liver regeneration
Research Interests: Understanding points of communication between the cell cycle machinery and cell shape controls, with particular reference to how these processes are simultaneously disrupted in cancer; the HEF1, HEI10, and HEI-C proteins, which function in cell cycle-cell attachment control pathways
Research Interests: Protein quaternary structure dynamics; the morpheein model of allosteric regulation; quaternary structure as a basis for understanding disease and discovering drugs
Research Interests: The Johnson laboratory studies mechanisms of DNA damage detection, repair, and signaling that occur in BRCA1 mutation-containing organisms and cancers. We use a range of approaches, including cell biology, mouse genetics, and therapy resistance modeling, to understand basic biological processes and their implications for tumorigenesis and chemotherapy sensitivity.
Research Interests: The goal of the Karanicolas laboratory is to develop structure-based approaches for modulating protein function using small-molecules. We apply these new approaches to re-activate disabled tumor suppressors, inhibit cancer-driving RNA-binding proteins, disable key oncogenic kinases, and tune the activity of antibodies used in cancer immunotherapy.
Research Interests: Molecular chaperone correction of missense mutations; genetic defects of methionine metabolic enzymes and human disease
Research Interests: Understanding mechanisms of drug resistance in gastrointestinal stromal tumors (GIST); preclinical testing of novel agents/combinations in GIST patient derived xenografts (PDX); identification of biomarkers of response to targeted agents in soft tissue sarcomas
Research Interests: Immune signaling and regulatory pathways in lymphoid malignancies
Research Interests: Genome stability in normal and disease states, mechanisms that ensure accurate chromosome segregation, mechanisms disrupted in cells with chromosome instability, strategies to enhance response of cancer cells to conventional chemoradiation therapies
* Physician's practice is independent of Drexel Medicine and Drexel University.