Joint Faculty Appointments
Research Interests: The focus of my research is the identification of novel biomarkers and therapeutic targets for the management and therapy of metastatic disease. We are particularly interested in the dissemination and growth of cancer cells in secondary organs such as skeleton, lungs and brain. My laboratory pursues a translational approach by employing cellular and molecular biology techniques combined with pre-clinical animal models of cancer growth and dissemination.
Research Interests: My laboratory is interested in understanding the changes in gene expression, translation, and metabolism that occur in response to hypoxia and cellular stress.
Research Interests: My laboratory focuses its research efforts on identifying and characterizing genes that are involved in pathogenesis of Alzheimer's disease (AD). We believe our efforts will lead to the identification of novel therapeutic strategies to delay or prevent onset of AD.
Research Interests: The goal of the laboratory is to understand the mechanisms involved in the lifespan extension provided by decreased growth hormone or insulin-like growth factors and to identify those settings in which supplementation can be of benefit late in life. Due to the broad nature of these questions our laboratory is drawn into diverse areas such as cancer, DNA repair, metabolism and neurobiology.
Research Interests: We investigate mitochondrial physiology, metabolism, and signaling in malaria parasites with a view to discover new drugs and to understand drug resistance.
Adjunct Biochemistry Faculty
Gordon J. Lutz, PhD
Research Interests: Our major research focus is to develop novel splice modulating oligomers (SMOs) as drugs to treat various serious neurological diseases, neuromuscular/muscular disorders and cancer.
Joseph Nickels, PhD
Adjunct Associate Professor of Biochemistry & Molecular Biology
PhD (1993) Microbiology & Immunogenetics, University of Medicine and Dentistry, New Jersey (UMDNJ)
Research Interests: Our laboratory has a basic research focus in two different areas. The first area is aimed at understanding the signals that are used in controlling the cell cycle. Under normal circumstances, the cell cycle is carefully controlled to ensure that cells replicate at the "right time." A loss of appropriate cell cycle signaling can result in uncontrolled growth, which often manifests itself as a form of cancer. The other focus of our laboratory is directed at an understanding of the checks and balances governing sterol synthesis. Sterol synthesis is one of the major therapeutic targets in the control of heart disease. Both of these research projects involve extremely complicated regulatory signals. To aid in our basic understanding, we have adopted the yeast system as a means of addressing our experimental questions.
Adjunct Biochemistry Faculty at Fox Chase Cancer Center
Visit Fox Chase Cancer Center
Research Interests: DNA repair of mismatched bases and the cellular response to DNA damage. Identification of early genetic alterations in tumorigenesis.
Research Interests: The field of epigenetics addresses the set of stable changes that influence gene expression patterns that do not arise from primary mutations in gene sequence. The primary focus of our research program is the translation of basic knowledge of the epigenetics of cancer to improve the early detection, prognosis, and prediction of response to treatment of cancer through novel and well-conceived molecular tests.
Research Interests: Signal transduction by small G proteins and their effectors and the role of these proteins in regulating cytoskeletal structure, tumor invasion, and metastasis; regulation of insulin signaling.
Research Interests: Tumor microenvironment and tumor-stroma interactions; a primary fibroblast-derived and in vivo-like 3D system that mimics stroma progression is used to investigate both the mechanisms of matrix induced myofibroblastic differentiation (e.g., desmoplastic activation) and the tumor-associated matrix induced permissiveness that promotes tumorigenesis and cell invasion. The stroma progressive 3D system also serves as basis for a platform investigating tumor-associated matrix induced drug responsiveness.
Research Interests: Computational structural biology, including homology modeling, fold recognition, molecular dynamics simulations, statistical analysis of the PDB and bioinformatics.
Research Interests: Understanding points of communication between the cell cycle machinery and cell shape controls, with particular reference to how these processes are simultaneously disrupted in cancer; the HEF1, HEI10, and HEI-C proteins, which function in cell cycle-cell attachment control pathways.
Research Interests: Protein structure-function relationships, the role of quaternary structure dynamics in allosteric regulation and drug action.
Research Interests: The role of dysregulated methionine metabolism and human diseases; correction of mutant protein function by chaperone therapy; mouse models of human disease.
Research Interests: Mechanisms of signaling transduction in cancer. Biochemical and cell biological approaches to understand how information is processed and transmitted in the cell.
Research Interests: Our laboratory is broadly interested in mechanisms that regulate genome stability and how these processes are disrupted in cancer cells. We are studying centromere and kinetochore function to understand the molecular defect that causes aneuploidy in cancer cells. We are also studying mechanisms in cancer cells that promote their survival in response to chemotherapy. The goal of our studies is to develop new strategies to enhance response of cancer cells to chemotherapy.
* Physician's practice is independent of Drexel Medicine and Drexel University.
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