Anthony Addison's personal page

Anthony W. Addison, Professor

B.Sc. (Hons.), 1968, University of New South Wales
Ph.D., 1971, University of Kent at Canterbury
Postdoctoral Fellow, 1970-72, Northwestern University
Assistant Professor, 1972-78, University of British Columbia.
At Drexel since 1978

Research Interests

Inorganic and Biophysical Chemistry: Molecular architecture of oxygen-binding and electron transfer metalloproteins; synthesis and chemistry of biomimetic inorganic complexes; electrochemistry of small molecules, electron spin resonance spectroscopy of copper(II) compounds, spectroscopy of metalloproteins.

Dr. Addison has published numerous papers in the areas of metalloprotein chemistry, the chemistry of non-macromolecular active-site models of metalloproteins, and the design of novel metal-receptor agents. He maintains active collaborations with x-ray crystallographic and other research groups in the U.S., Canada, the U.K., Switzerland, and the Netherlands."Classical biochemistry is acceding to the reality that a large number of physiologically important biological macromolecules owe their functional activity to the presence of one or more metal ions in their structures. We are engaged both in isolating and studying these natural sytems and in synthesis of "unnatural" molecules, whose behaviours are designed to reveal to us clues to the mysteries of these metalloprotein active sites."

Selected Publications

 Biological Chemistry:

 •  J. J. Stephanos, S. A. Farina & A. W. Addison*, "Iron Ligand Recognition by Monomeric Hemoglobins."  Biochimica et Biophysica Acta, 1295, 209-221 (1996).

 •  T.J. DiFeo & A.W. Addison*, "Heme Rotational Isomerism is Not Required for the Production of Q-Band Splitting in the Spectra of Iron-Porphyrin Proteins", Inorganic Chemistry, 30, 1151-1153 (1991).

 •  T.J. DiFeo & A.W. Addison*, "Kinetic and Spectroscopic Studies of Hæmoglobin and Myoglobin from the Echiuran Urechis caupo - Distal Residue Effects", The Biochemical Journal, 269, 739-747 (1990).

 •  T.J. DiFeo and A.W. Addison*, "Hæm Cotton Effects of Glycera dibranchiata Monomeric Hæmoglobin and Equine Myoglobin Reconstituted with Synthetic and Natural Iron Porphyrins", The Biochemical Journal, 260, 863-871 (1989).

 •  A.W. Addison* and J.J. Stephanos, "Nitrosyliron(III) Hemoglobin: Autoreduction and Spectroscopy", Biochemistry, 25, 4104-4113 (1986).

 •  J.L. Smith, W.A. Hendrickson* and A.W. Addison, "Structure of Trimeric Hæmerythrin", Nature (London), 303 (5912), 86-88 (1983).

 

Inorganic Chemistry

 • S. Ghosh, K. K. Nanda, A. W. Addison* and R. J. Butcher, "Mononuclear and Mixed-valence Binuclear Oxovanadium Complexes with Benzimidazole-derived Chelating Agents", Inorganic Chemistry, 40(8), 2243-2249 (2002)  [Web-published 2002/03/23]

 • V. V. Pavlishchuk*, S. V. Kolotilov, A. W. Addison, M. J. Prushan, R. J. Butcher and L. K. Thompson, "A new class of macrocyclic complexes formed via nickel-promoted macrocyclisation of dioxime with dinitrile."  Journal of the Chemical Society, Chemical Communications (2002) 468-469.

 •  V. V. Pavlishchuk*, S. V. Kolotilov, A. W. Addison*, M. J. Prushan, D. Schollmeyer, L. K. Thompson and E A. Goreshnik, "A Tetrameric Nickel(II) "Chair" with both Antiferromagnetic Internal Coupling and Ferromagnetic Spin Alignment." Angewandte Chemie, International Edition, 40, 4734-4737 (Dec. 2001).

 •  J. G. Gilbert, A. W. Addison*, A. Y. Nazarenko and R. J. Butcher, "Copper(II) complexes of new unsymmetrical NSN thioether ligands", Inorganica Chimica Acta, 324, 123-130 (Nov. 2001).

 •  J. G. Gilbert, A. W. Addison* & R. J. Butcher, "Some Nickel(II) Complexes with Pentadentate and Tridentate Heterocyclic N- and S-Donor Ligands", Inorganica Chimica Acta, 308, 22-30 (Oct. 2000).

 •  V. V. Pavlishchuk*, I. A. Koval, E. Goreshnik, A. W. Addison*, G. A. van Albada and J. Reedijk, "The First Example of a True “Turnbull’s Blue” Family Compound with Trapped Iron Oxidation States", The European Journal of Inorganic Chemistry, 297-301 (Jan. 2001).

•  V. V. Pavlishchuk*, S. V. Kolotilov, A. W. Addison*, R. J. Butcher and E. Sinn, "Nickel(II) complexes with dithiadiiminoamine and dithiabis(thiosemicarbazone) ligands." Journal of the Chemical Society, Dalton Transactions, 335-341 (2000).

 •  M. J. Prushan, A. W. Addison* and R. J. Butcher, "Pentadentate Thioether Oxime Macrocyclic and Quasi-Macrocyclic Complexes of Copper(II) and Nickel(II)", Inorganica Chimica Acta, 300-302, 992-1003 (April 2000).

 • V. V. Pavlishchuk and A. W. Addison*, "Conversion Constants for Redox Potentials Measured vs. Different Reference Electrodes in Acetonitrile Solutions at 25 °C", Inorganica Chimica Acta, 298, 97-102 (Feb. 2000).

•  V. V. Pavlishchuk, S. V. Kolotilov, A. W. Addison, M. J. Prushan, R. J. Butcher and L. K. Thompson, "Mono- and Trinuclear Nickel(II) Complexes with Sulfur-Containing Oxime Ligands: Uncommon Templated Coupling of Oxime with Nitrile", Inorganic Chemistry, 38, 1759-1766 (1999).

 •  K. K. Nanda, A. W. Addison,* N. Paterson, E. Sinn, L. K. Thompson and U. Sakaguchi, "Copper(II) and Nickel(II) Complexes of Anionic Dinucleating Macrocycles."  Inorganic Chemistry, 37, 1028-1036 (1998).

 •  K. K. Nanda, A. W. Addison*, R. J. Butcher, M. R. McDevitt, T. N. Rao and E. Sinn, "Structural Demonstration of The Rôle of Ligand Framework Conformability in Copper(II)/ Copper(I) Redox Potentials." Inorganic Chemistry, 36, 134-135 (1997) (Communication to the Editor).

 •  A. W. Addison, "Electron-Counting Rules for Transition Metal- Nitric Oxide Complexes", Journal of Chemical Education, 74, 1354-1356, (1997).

 •  K. K. Nanda, A. W. Addison*, E. Sinn & L. K. Thompson, "Helical Antiferromagnetic Copper(II) Chains with a Collagen Structural Motif", Inorganic Chemistry, 35, 5966-7 (1996) (Communication to the Editor).

 •  M. Palaniandavar, R. J. Butcher and A. W. Addison*, "Dipicolylamine Complexes: Two Different Copper Coordination Geometries in the Same Unit Cell: Bis(dipicolylamine)copper(II) Tetrafluoroborate."  Inorganic Chemistry, 35, 467-471 (1996).

•  K. K. Nanda, A. W. Addison* & E. Sinn, "The First Oxovanadium(V) Thiolate Complex, [VO(SCH2CH2)3N]".  Inorganic Chemistry, 35, 1-2  (1996) (Communication to the Editor).

 •  V. V. Pavlishchuk, A. W. Addison*, R. J. Butcher & R. P. F. Kanters, "A Nickel Dithiadioxime Derived Macrocycle", Inorganic Chemistry, 33, 397-399 (1994).

 •  M.R. McDevitt & A.W. Addison*, "Medium Effects on the Redox Chemistry of Tris(2,2'-bipyridyl)-ruthenium Complexes", Inorganica Chimica Acta, 204, 141-146 (1993).

 •  R.P.F. Kanters, R. Yu & A.W. Addison*, “Some High-Potential Trithioether Chelates of Copper”, Inorganica Chimica Acta, 196, 97-102 (1992).

 •  M.R. McDevitt, A.W. Addison*, E. Sinn* & L.K. Thompson, "Analogues for the Specific Iron-Binding Site of Transferrin: Structure of a Ternary Complex and Spectroscopic and Reactivity Properties of Related Model Compounds", Inorganic Chemistry, 29, 3425-3433 (1990).

 •  A.W. Addison, "Is Ligand Topology A Structural Influence on the Redox Potentials of Copper Complexes ?", Inorganica Chimica Acta, 162, 217-220 (1989).

 •  A. W. Addison*, S. Burman, C. G. Wahlgren, O. A. Rajan, T. M. Rowe and E. Sinn*, "New Iron(II) Spin Crossover Complexes with Heterocyclic Amine-Derived Ligands and STEPS Experiments on Photo-generated Metastable High-Spin States", The Journal of the Chemical Society, Dalton Transactions, 2621-2630 (1987).

 •  A.W. Addison*, T.N. Rao and E. Sinn, "Spectroscopy and Structure of Thiolate and Thioether Complexes of Copper(II), and the Relationship of Their Redox Properties to Certain Copper Proteins", Inorganic Chemistry, 23, 1957-1967 (1984).

 •  A.W. Addison*, T.N. Rao, J. Reedijk*, J. van Rijn and G.C. Verschoor, "Synthesis, Structure and Spectroscopic Properties of Copper(II) Compounds Containing Nitrogen-Sulphur Donor Ligands; the Crystal and Molecular Structure of Aqua[1,7-bis(N-methylbenzimidazol-2-yl)-2,6-dithiaheptane]-copper(II) Perchlorate", The Journal of the Chemical Society, Dalton Transactions, 1349-1356 (1984).

 •  A.W. Addison* and E. Sinn, "A Stable Bis-Thiolate of Copper(II) With Long Axial Copper-Sulfur Linkages: Crystal and Molecular Structure of trans-[Cu(Cyclam)(SC6F5)2]", Inorganic Chemistry, 22, 1225-1228 (1983).

 •  E.W. Ainscough*, A.M. Brodie, J.E. Plowman, K.L. Brown, A.W. Addison and A.R. Gainsford, "Small Molecule Analogues for the Specific Iron-Binding Site of Lactoferrin: A Single Crystal X-ray Structure of Bis(methanol)bis[2-(5-methylpyrazol-3-yl)phenolato]iron(III) Nitrate Methanol and Spectroscopic Studies on Iron(II)-Phenolate Complexes", Inorganic Chemistry, 19, 3655-3663 (1980).

 •  U. Sakaguchi and A.W. Addison* "Spectroscopic and Redox Studies of Some Copper(II) Complexes with Biomimetic Donor Atoms: Implications for Protein Copper Centres", The Journal of the Chemical Society, Dalton Transactions, 600-608 (1979)

 •  A.W. Addison*, M. Carpenter, L.K-M. Lau and M. Wicholas*, "Coordination Sphere Flexibility at Copper: Chemistry of a Unipositive Copper(II) Macrocycle, Cu(cyclops)+", Inorganic Chemistry, 17, 1545-1552 (1978).

 •  U. Sakaguchi and A.W. Addison*, "Structural Implications for Blue Protein Copper Centers from Electron Spin Resonance Spectra of Cu(II)S4 Chromophores", Journal of the American Chemical Society, 99, 5189-5190 (1977).

 •  H. Yokoi and A.W. Addison*, "Spectroscopic and Redox Properties of Pseudotetrahedral Copper(II) Complexes. Their Relationship to Copper Proteins." Inorganic Chemistry, 16, 1341-1349 (1977).

•  A.W. Addison, "One-Electron Redox Processes at Binuclear Copper Centres", Inorganic & Nuclear Chemistry Letters, 12, 899-903 (1976).