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  Nianli Sang, M.B., Ph.D.  
 

Position(s):
Associate Professor, Dept. of Biology

  
       
 

Office: Stratton 318
Lab: Stratton 307 

Phone: (215) 895-1888 (Office)
            (215) 895-1436(Lab)

Email: nianli.sang@drexel.edu

 
 
 
  Educational Information


M.B. - Fudan University Shanghai Medical College, China: Medicine (M.D. equivalent)
M. Surgery - Fudan University Shanghai Medical College Zhongshan Hospital: Surgery
(Redisdent Training equivalent)
Ph.D. - Genetics, Thomas Jefferson University Kimmel Cancer Center, Philadelphia

  
     
 

Courses Taught

BIO311: Metabolism
BIO610: Biochemistry

  
 
 
  Research Focus

Molecular oxygen is an absolute requirement for the metabolism of most organisms on the earth including all animals. Hypoxia-inducible factors 1 and 2 (HIF-1, HIF-2, and collectively, HIF) are heterodimeric nuclear transcription factors regulated by oxygen and various signaling pathways.  It has been generally that they are the master regulators of angiogenesis, coupled glucose-oxygen metabolism and response to biological stresses, which are triggered by a variety of biological and pathological conditions ranging from early development, tumorigenesis, ischemic disorders, diabetes, aging and infectious diseases.

My current research focuses on four intrinsically related issues: 1) To understand the cellular, molecular and biochemical bases underlying the regulation of HIF function in normal and tumor cells; 2) To understand the biochemical and pharmacological mechanisms underlying the repressive effects of chemotherapeutics on HIF activity; 3) To investigate the roles of HIF in the physiology and pathophysiology of endothelial cells and neurons, emphasizing on molecular, biochemical and cellular bases of human diseases; and 4) To explore potential application of the HIF system in novel diagnosis and therapies for human diseases.

To view some of Dr. Sang's published work [...click here...]

 
     
 

Lab Staff 

Liang, Dongming, B.S., Research Technician


Lao, Taotao, Ph.D. Candidate
  
 
 
 

Active Research Funding:

R01-CA129494                                                                 08/01/2008-07/30/2013
NIH/National Cancer Institute                                                                  
 “Repressing HIF-1: Targets and Mechanisms