Selected Publications

Lechner, M.S. and Laimins, L.A. Human epithelial cells immortalized by SV40 retain
differentiation capabilities in an in vitro raft system and maintain viral DNA
extrachromasomally. Virology 185:563-571. 1991

Lechner, M.S., Mack, D.H., Finicle, A.B., Crook, T., Vousden, K.H., and Laimins,
L.A. Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated
repression of transcription. EMBO J. 11:3045-3052. 1992

Lechner, M.S., and Laimins, L.A. Inhibition of p53 DNA binding by human
papillomavirus E6 proteins. J. Virol. 68:4262-4273. 1994

Lechner, M.S. and Dressler, G. R. Mapping of Pax-2 transcription activation domains.
J. Biol. Chem. 271:21088-21093. 1996

Dehbi, M., Ghahremani, M., Lechner, M., Dressler, G., and Pelletier, J. The paired-box
transcription factor, PAX2, positively modulates expression of the Wilm’s tumor
suppressor gene (WT1). Oncogene 13:447-453. 1996

Vega, Q.C., Worby, C.D., Lechner, M.S., Dixon, J.E., and Dressler, G.R. Glial cell
line-derived neurotrophic factor activates RET and promotes kidney morphogenesis.
Proc. Natl. Acad. Sci. USA 93:10657-10661. 1996

Lechner, M.S., and Dressler, G.R. The molecular basis of embryonic kidney
development. Mech. Of Dev. 62:105-120. 1997

Phippard, D., Heydemann, A., Lechner, M., Lu, L., Lee, D., Kyin, T., and Crenshaw,
E.B. III. Changes in the subcellular localization of the Brn4 gene product precede
mesenchymal remodeling of the otic capsule. Hear Res. 120(1-2):77-85. 1998

Lechner, M.S. Levitan, I. and Dressler, G.R. PTIP: a novel BRCT-domain-containing
protein interacts with Pax-2. Nucleic Acids Res. 28:2741-2751. 2000

Lechner, M.S., Begg, G.E., Speicher, D.W. and Rauscher, F.J. III. Molecular
determinants for targeting HP1-mediated gene silencing: a direct chromoshadow
domain-KAP-1 corepressor interaction is essential. Mol. Cell Biol. 20:6449-6465. 2000

Cai, Y., Lechner, M.S., Prindle, M.J., Nihilani, D., Holzman, L.B., and Dressler,
G.R. Phosphorylation of Pax2 by c-Jun N-terminal kinase and enhanced Pax2-
dependent transcription activation. J. Biol. Chem. 277:1217-1222. 2002

Ayyanathan, K., Lechner, M.S., Bell, P., Maul, G.G., Schultz, D.C., Yamada,
Y., Tanaka, K., Torigoe, K., Rauscher, F.J.III. Regulated recruitment of HP1 to a
euchromatic gene induces mitotically heritable, epigenetic gene silencing: a
mammalian cell culture model of gene variegation. Genes Dev. 17:1855-1869. 2003

Hu, X. and Lechner, M. Extracting biological relationships from Medline abstracts.
IEEE ICDM International Workshop on Foundations and New Directions in Data
Mining,. Nov. 19-22, 2003.

Hu, X., Lin, T.Y. , Song I-Y, Lin, X., Yoo, I., Lechner, M., Song, M. Ontology-based
Scalable and Portable Information Extraction System to Extract Biological Knowledge
from Huge Collection of Biomedical Web Documents. IEEE International Conference
on Web Intelligence . September 13-17 th, 2004.

Lechner, M.S. Schultz, D.C. Negorev, D., Maul, G.G., and Rauscher, F.J. III. The
mammalian heterochromatin protein 1 binds diverse nuclear proteins through a
common motif that targets the chromoshadow domain. Biochem. Biophys. Res.
Comm. 331:929-937.