Joe P. Foley, Professor

B.S., Centre College of Kentucky,1978.
Ph.D., University of Florida, 1983.
National Research Council Postdoctoral Fellow, National Institute of Standards and Technology, 1983-85.
Assistant Professor of Chemistry, Louisiana State University, 1985-91.
Associate Professor of Chemistry, Louisiana State University, 1991.
Associate Professor of Chemistry, Villanova University, 1991-97.
Professor of Chemistry, Villanova University,1997-98.

Professor of Chemistry, Drexel University, 1998 - present
Visiting Professor of Chemistry, University of Frankfurt (Germany), 2006-07

Editorial boards

Bioanalysis, June 2008 - present
Electrophoresis, October 2007 - present
The Analyst, 1991 - 2000
Journal of Microcolumn Separations, 1991 - 2001
Analytical Communications, 1996 - 1999

Research interests

Within each of the above categories (as appropriate), our research group is interested in the following: novel separation media; separation and/or retention mechanisms; linear free energy and solvatochromic relationships; quantitative structure retention relationships/QSAR; secondary chemical equilibria, especially organized media (micelles, microemulsions, vesicles, etc.); physicochemical measurements; biological partition processes; biomedical and pharmaceutical applications; and peak shape analysis/chromatographic figures of merit.

Detailed description of research interests »
Ph.D. graduates from the Foley research group »
M.S. graduates from the Foley research group »
Research group photo »

Selected Publications by Category

Capillary Electrophoresis and Electrokinetic Chromatography

High Performance and Two-Dimensional Liquid Chromatography

Chromatographic Figures of Merit

Supercritical Fluid Chromatography and Extraction

Tutorials and Critical Reviews

Environmental/Natural Products

Capillary Electrophoresis and Electrokinetic Chromatography

Kojtari, A.; Foley, J. P.  Effect of Microemulsion Component Purity on the Chromatographic Figures of Merit in Chiral Microemulsion Electrokinetic Chromatography, J. Chromatogr. A., 2009, in press. (invited paper)

Kahle, K. A.; Foley, J. P.  "Chiral Microemulsion Electrokinetic Chromatography", in Chiral Separations by Capillary Electrophoresis, Yvette Michotte and Ann Van Eeckhaut, Eds.; CRC Press, 2009, in press.  

Foley, J. P.; Hong, M.; Polinko, M. A.; Pascoe, R. J.; Ahuja, E. S. Compositional Effects on Electrophoretic and Chromatographic Figures of Merit in Electrokinetic Chromatography with Cetyltrimethylammonium Bromide/Sodium Octyl Sulfate Vesicles as the Pseudostationary Phase. Part 1: Effect of the Phase Ratio, Electrophoresis 2008, 29, 1180-1188.

Kahle, K. A.; Foley, J. P.  Influence of Microemulsion Chirality on Chromatographic Figures of Merit in Electrokinetic Chromatography:  Results with Novel Three-Chiral-Component Microemulsions and Comparison with One- and Two-Chiral-Component Microemulsions. Electrophoresis, 2007, 28, 3024-3040. (invited paper)

Kahle, K. A.; Foley, J. P.  Review of Aqueous Chiral Electrokinetic Chromatography with an Emphasis on Chiral Microemulsion EKC. Electrophoresis, 2007, 28, 2503-2526. (invited review)

Kahle, K. A.; Foley, J. P.  Two-Chiral-Component Microemulsion Electrokinetic Chromatography—Chiral Surfactant and Chiral Oil: Part 2. Diethyl Tartrate. Electrophoresis, 2007, 28, 2644-2657. (invited paper)

Weekley, B. S.; Foley, J. P.  Dual-opposite-injection CZE: theoretical aspects and application to organic and pharmaceutical compounds, Electrophoresis 2007, 28, 697-711. (invited paper)

Thomas, D. P.; Foley, J. P.  Efficiency enhancements in micellar liquid chromatography through selection of stationary phase and alcohol modifier, J. Chromatogr. A 2007, 1149, 282-293.

Kahle, K. A.; Foley, J. P.  Two-chiral-component microemulsion electrokinetic chromatography-chiral surfactant and chiral oil: Part 1. Dibutyl tartrate, Electrophoresis 2007, 28, 1723-1734.

Zhou, M. X.; Foley, J. P.  Quantitative Theory of Electroosmotic Flow in Fused-Silica Capillaries Using an Extended Site-Dissociation-Site-Binding Model, Anal. Chem. 2006, 78, 1849-1858.

Pascoe, R. J.; Masucci, J. A.; Foley, J. P.  Investigation of vesicle electrokinetic chromatography as an in vitro assay for the estimation of intestinal permeability of pharmaceutical drug candidates, Electrophoresis 2006, 27, 793-804.

Kahle, K. A.; Foley, J. P.  Chiral microemulsion electrokinetic chromatography: effect of cosurfactant identity on enantioselectivity, methylene selectivity, resolution, and other chromatographic figures of merit, Electrophoresis 2006, 27, 4321-4333.

Kahle, K. A.; Foley, J. P.  Chiral microemulsion electrokinetic chromatography with two chiral components: improved separations via synergies between a chiral surfactant and a chiral cosurfactant, Electrophoresis 2006, 27, 896-904.

Erdner, J. M.; Barth, H. G.; Foley, J. P.; Payne, W. G.  Size-exclusion chromatography using deuterated mobile phases, J. Chromatogr. A 2006, 1129, 41-46.

Schuster, S. A.; Foley, J. P.  Effect of surfactant counterion and organic modifier on the properties of surfactant vesicles in electrokinetic chromatography, J. Sep. Sci. 2005, 28, 1399-1408.

Mertzman, M. D.; Foley, J. P.  Comparison of dodecoxycarbonylvaline microemulsion, solvent-modified micellar and micellar pseudostationary phases for the chiral analysis of pharmaceutical compounds, Electrophoresis 2005, 26, 4153-4163.

Mertzman, M. D.; Foley, J. P.  Temperature effects on chiral microemulsion electrokinetic chromatography employing the chiral surfactant dodecoxycarbonylvaline, J. Chromatogr. A 2005, 1073, 181-189.

Zhou, M. X.; Foley, J. P.  Analytical Method for the Quantitation of Sertraline Hydrochloride Stereoisomers by Electrokinetic Chromatography, J. Chromatogr. A 2004, 1052, 13-23.

Mertzman, M. D.; Foley, J. P.  Effect of surfactant concentration and buffer selection on chromatographic figures of merit in chiral microemulsion electrokinetic chromatography, Electrophoresis 2004, 25, 3247-3256.

Mertzman, M. D.; Foley, J. P.  Chiral Cyclodextrin-Modified Microemulsion Electrokinetic Chromatography.  Electrophoresis, 2004, 25, 1188-1200.

Mertzman, M. D.; Foley, J. P. Effect of Oil Substitution in Chiral Microemulsion Electrokinetic Chromatography. Electrophoresis, 2004, 25, 723-732.

Zhou, M.; Foley, J. P. Dual Opposite Injection Electrokinetic Chromatography: Nonionic Microemulsion Pseudostationary Phase and Novel Approach to Electrokinetic Sampling Bias. Electrophoresis, 2004, 25, 653-663.

Pascoe, R. J.; Foley, J. P. Comparison of Synthetic Surfactant Vesicles and Biological Liposomes as Pseudostationary Phases in Electrokinetic Chromatography. Electrophoresis, 2003, 24, 4227-4240.

Lucas, C.; Foley, J.P.; Ahuja, E.S. Analysis of Glycopeptide Antibiotics using Micellar Electrokinetic Chromatography and Borate Complexation. Biomed. Chromatogr. 2003, 17,172-181.

 Pascoe, R.;  Foley, J.P.  Rapid Separation of Pharmaceutical Enantiomers Using Electrokinetic Chromatography With a Novel Chiral Microemulsion. The Analyst, 2002, 127, 710-714.

Pascoe, R.;  Foley, J.P.  Effect of Class I and II Organic Modifiers on Selectivity and Retention in Vesicle Electrokinetic Chromatography. Electrophoresis, 2002, 23, 1618-1627.

Klotz, W. L.;  Schure,M.R.; Foley, J.P.  Rapid Estimation of Octanol-Water Partition Coefficients Using Synthesized Vesicles in Electrokinetic Chromatography.J. Chromatogr. A, 2002, 962, 207-219. 

Klotz, W. L.; Schure, M. R.; Foley, J. P. Determination of Octanol-Water Partition Coefficients of Pesticides by Microemulsion Electrokinetic Chromatography. J. Chromatogr. A 2001, 930, 145-154.

Lucas, C.; Gliddon, M.; Safarpour, M.; Cardaciotto, S.; Ahuja, E. S.; Foley, J. P. Determination of Avoparcin in Animal Formulations by Capillary Electrophoresis. J. Cap. Electrophoresis 1999, 6, 75-83 (published in April 2001).

Durkin, D. P.; Foley, J. P. Dual-Opposite Injection Electrokinetic Chromatography for the Unbiased, Simultaneous Separation of Cationic and Anionic Compounds. Electrophoresis 2000, 21, 1997-2009.

Pascoe, R. J.; Peterson, A. G.; Foley, J. P. Investigations of the Chiral Surfactant N-dodecoxycarbonylvaline in Electrokinetic Chromatography: Improvements in Elution Range and pH Stability via Mixed Micelles and Vesicles, and the Hydrophobicity Determination of Basic Pharmaceutical Drugs. Electrophoresis 2000, 21, 2033-2042.

Hong, M.; Weekley, B. S.; Grieb, S. J.; Foley, J. P. Electrokinetic Chromatography Using Thermodynamically-Stable Vesicles and Mixed Micelles Formed from Oppositely Charged Surfactants. Anal. Chem. 1998, 70, 1394-1403.

Lewis, R. E.; Ahuja, E. S.; Foley, J. P. Ion Analysis by Capillary Zone Electrophoresis with Indirect Detection: Applications in the Nuclear Power Industry. Analyst 1998, 123, 1465-1469.

Nielsen, K. R.; Foley, J. P. "Micellar Electrokinetic Chromatography," In Capillary Electrophoresis - Theory and Practice; Camilleri, P., Ed.; CRC Press: Boca Raton, 1998, pp 135-182.

Harrell, C. W.; Dey, J.; Shamsi, S. A.; Foley, J. P.; Warner, I. M. Enhanced Separation of Antidressants Drugs Using a Polymeric Surfactant as a Transient Capillary Coating. Electrophoresis 1998, 19, 712-718.

Masucci, J. A.; Caldwell, G. W.; Foley, J. P. A Comparison of the Retention Behavior of B-Blockers Using Immobilized Artificial Membrane Chromatography and Lysophospholipid Micellar Electrokinetic Chromatography. J. Chromatogr. A 1998, 810, 95-103.

Peterson, A. G.; Foley, J. P. Influence of the Inorganic Counterion on the Thermodynamic Quantities of Micellar Solubilization of Chiral Pharmaceutical Compounds in Aqueous Solutions of N-Dodecoxycarbonylvaline using Micellar Electrokinetic Chromatography. J. Microcol. Sep. 1998, 10, 633-645.

Roddy, T. P.; Molnar, T. E.; McKean, R. E.; Foley, J. P. A Method of Analysis of Recombinant Acidic Fibroblast Growth Factor (aFGF) by Capillary Electrophoresis. J. Chromatogr. B 1997, 695, 49-58.

Peterson, A. G.; Foley, J. P. Influence of the Inorganic Counterion on the Chiral Micellar Electrokinetic Separation of Basic Drugs Using the Surfactant N-dodecoxycarbonylvaline. J. Chromatogr. B 1997, 695, 131-145.

Peterson, A. G.; Ahuja, E. S.; Foley, J. P. Enantiomeric Separations of Basic Pharmaceutical Drugs by Micellar Electrokinetic Chromatography Using a Chiral Surfactant, N-Dodecoxycarbonylvaline. J. Chromatogr. B 1996, 683, 15-28.

Peterson, A. G.; Foley, J. P. Determining Thermodynamic Quantities of Micellar Solubilization of Chiral Pharmaceutical Compounds in Aqueous Solutions of N-Dodecoxycarbonylvaline Using Micellar Electrokinetic Chromatography. J. Microcol. Sep. 1996, 8, 427-437.

Foley, J. P.; Ahuja, E. S. "Electrokinetic Chromatography," In Pharmaceutical and Biomedical Applications of Capillary Electrophoresis; Lunte, S. M., Radzik, D. M., Eds.; Pergamon Press: Tarrytown, New York, 1996; Vol. 2, pp 81-178.

Ahuja, E. S.; Little, E. L.; Nielsen, K. R.; Foley, J. P. Infinite Elution Range in Micellar Electrokinetic Capillary Chromatography Using a Nonionic/Anionic Mixed Micellar System. Anal. Chem. 1995, 67, 26-33.

Ahuja, E. S.; Foley, J. P. Influence of dodecyl sulfate counterion on efficiency, selectivity, retention, elution range, and resolution in micellar electrokinetic chromatography. Anal. Chem. 1995, 67, 2315-2324.

Ahuja, E. S.; Foley, J. P. A Retention Index for Micellar Electrokinetic Chromatography. Analyst 1994, 119, 353-360.

Ahuja, E. S.; Foley, J. P. Separation of Very Hydrophobic Compounds by Hydrophobic Interaction Electrokinetic Chromatography. J. Chromatogr. A 1994, 680, 73-83.

Nielsen, K. R.; Foley, J. P. Zone sharpening of neutral solutes in micellar electrokinetic chromatography with electrokinetic injection. J. Chromatogr. A 1994, 686, 283-291.

Ahuja, E. S.; Preston, B. P.; Foley, J. P. Anionic/Zwitterionic Mixed Micelles in Micellar Electrokinetic Chromatography: Sodium dodecyl sulfate / N-dodecyl-N,N-dimethylammonium-3-propane-1-sulfonic acid. J. Chromatogr. B 1994, 657, 271-284.

Nielsen, K. R.; Foley, J. P. Effect of the Dodecyl Counter Ion on Selectivity and Resolution in Micellar Electrokinetic Capillary Chromatography: II. Organic Counterions. J. Microcol. Separ. 1994, 6, 139-149.

Nielsen, K. R.; Foley, J. P. "Micellar Electrokinetic Capillary Chromatography," In Capillary Electrophoresis - Theory and Practice; Camilleri, P., Ed.; CRC Press: Boca Raton, 1993, pp 117-161.

Nielsen, K. R.; Foley, J. P. Effect of the Dodecyl Counter Ion on Selectivity and Resolution in Micellar Electrokinetic Capillary Chromatography: SDS vs. Mg(DS)2. J. Microcol. Separ. 1993, 5, 347-360.

Ahuja, E. S.; Little, E. L.; Foley, J. P. Selected Organic Solvents as Electroosmotic Velocity Markers in Micellar Electrokinetic Capillary Chromatography. J. Liq. Chromatogr. 1992, 15, 1099-1113.

Little, E. L.; Foley, J. P. Optimization of the Resolution of PTH-Amino Acids Through Control of Surfactant Concentration in Micellar Electrokinetic Capillary Chromatography. J. Microcol. Separ. 1992, 4, 145-154.

Foley, J. P. Optimization of Micellar Electrokinetic Chromatography. Anal. Chem. 1990, 62, 1302-1308.

Ghowsi, K.; Foley, J. P.; Gale, R. J. Micellar Electrokinetic Capillary Chromatography Theory Based on Electrochemical Parameters: Optimization for Three Modes of Operation. Anal. Chem. 1990, 62, 2714-2721.

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High Performance and Two-Dimensional Liquid Chromatography

Thomas, D. P.; Foley, J. P.  Improved Efficiency in Micellar Liquid Chromatography Using Triethylamine and 1-Butanol as Mobile Phase Additives to Reduce Surfactant Adsorption.  J. Chromatogr. A., 2008, 1205, 36-45. 

Jantratid, E., Sompol Prakongpan, S.; Foley, J. P.; Dressman, J. B.  Convenient and Rapid Determination of Cimetidine in Human Plasma using Perchloric Acid-Mediated Plasma Protein Precipitation and High-Performance Liquid Chromatography. Biomed. Chromatogr., 2007, 21, 949-957.

Thomas, D. P.; Foley, J. P.  Efficiency Enhancements in Micellar Liquid Chromatography Through Selection of Stationary Phase and Alcohol Modifier.  J. Chromatogr. A.  2007, 1149, 282-293.

Thomas, D. P.; Foley, J. P.  Stationary Phase Effects on Efficiency in Micellar Liquid Chromatography.  J. Chromatogr. A.  2004, 1061, 195-203.

McCormick, T. J.; Foley, J. P.; Lloyd, D.K. Chromatographic Performance of Large-Pore Versus Small-Pore Columns in Micellar Liquid Chromatography. J. Chromatogr. B. 2003, 785, 1-20.

Pascoe, R. J.; Foley, J. P.; Gusev, A. I. Reduction in Matrix-Related Signal Suppression Effects in Electrospray Ionization Mass Spectrometry (ESI-MS) Using On-Line Two-Dimensional Liquid Chromatography. Anal. Chem. 2001, 73,6014-6023.

McCormick, T. J.; Foley, J. P.; Lloyd, D.; Riley, C. M. The Effect of Stationary Phase Pore Size on Retention in Micellar Liquid Chromatography. Anal. Chem. 2000, 72, 294-301.

Murphy, R. E.; Schure, M. R.; Foley, J. P. Effect of Sampling Rate on Resolution in Comprehensive Two-Dimensional Liquid Chromatography. Anal. Chem. 1998, 70, 1585-1594.

Murphy, R. E.; Schure, M. R.; Foley, J. P. One and Two-Dimensional Analysis of Alcohol Ethoxylates. Anal. Chem. 1998, 70, 4353-4360.

Murphy, R. E.; Schure, M. R.; Foley, J. P. Quantitative Analysis of Poly(Methyl Methacrylate/Butyl Acrylate) Copolymer Composition by Liquid Chromatography-Particle Beam-Mass Spectrometry. J. Chromatogr. A 1998, 824, 181-194.

Arenas, R. V.; Foley, J. P. Selectivity of Polymer-Coated Unisphere Aluminas for Reversed-Phase Liquid Chromatography: I. Methylene Group Selectivity. Analyst 1994, 119, 1303-1314.

Little, E. L.; Jeansonne, M. S.; Foley, J. P. Sequential Multimodal Elution for Pseudomultidimensional Liquid Chromatography on a Single Column. Anal. Chem. 1991, 63, 33-44.

Arenas, R. V.; Foley, J. P. Solvent Strength, Selectivity, and Retention Mechanism Studies of Polybutadiene-Coated Alumina Columns in Reversed-Phase Liquid Chromatography. Anal. Chim. Acta 1991, 246, 113-130.

Foley, J. P. Resolution Equations for Column Chromatography. Analyst 1991, 116, 1275-1279.

Foley, J. P. Critical Compilation of Solute-Micelle Binding Constants and Related Parameters from Micellar Liquid Chromatographic Measurements. Anal. Chim. Acta 1990, 231, 237-247.

Foley, J. P.; Crow, J. A.; Thomas, B. A.; Zamora, M. Unavoidable Flow Rate Errors in High Performance Liquid Chromatography. J. Chromatogr. 1989, 478, 287-309.

Foley, J. P. Separation of m-Cresol and p-Cresol and Other Methylated Phenols in Shale Oil by Reversed Phase Liquid Chromatography with Electrochemical Detection. J. Chromatogr. 1988, 441, 347-354.

Foley, J. P.; May, W. E. Optimization of Secondary Chemical Equilibria in Liquid Chromatography: Theory and Verification. Anal. Chem. 1987, 59, 102-109.

Foley, J. P.; May, W. E. Optimization of Secondary Chemical Equilibria in Liquid Chromatography: Variables Influencing the Self-Selectivity, Retention, and Efficiency. Anal. Chem. 1987, 59, 110-116.

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Chromatographic Figures of Merit

Jeansonne, M. S.; Foley, J. P. Improved Equations for Calculation of Chromatographic Figures of Merit for Ideal and Skewed Peaks. J. Chromatogr. 1992, 594, 1-8.

Jeansonne, M. S.; Foley, J. P. Review of the Exponentially Modified Gaussian Chromatographic Peak Model Since 1983. J. Chromatogr. Sci. 1991, 29, 258-266.

Jeansonne, M. S.; Foley, J. P. Measurement of Statistical Moments of Resolved and Overlapping Chromatographic Peaks. J. Chromatogr. 1989, 461, 149-163.

Foley, J. P. Equations for Chromatographic Peak Modeling and Calculation of Peak Area. Anal. Chem. 1987, 59, 1984-1987.

Foley, J. P. Systematic Errors in the Measurement of Peak Area and Peak Height for Overlapping Peaks. J. Chromatogr. 1987, 384, 301-313.

Foley, J. P.; Dorsey, J. G. Clarification of the Limit of Detection in Chromatography. Chromatographia 1984, 18, 503-511.

Foley, J. P.; Dorsey, J. G. A Review of the Exponentially Modified Gaussian (EMG) Function: Evaluation and Subsequent Calculation of Universal Data. J. Chromatogr. Sci. 1984, 22, 40-46.

Foley, J. P.; Dorsey, J. G. Equations for Calculation of Chromatographic Figures of Merit for Ideal and Skewed Peaks. Anal. Chem. 1983, 55, 730-737.

Supercritical Fluid Chromatography and Extraction

Foley, J. P.; Crow, J. A. "Systematic Multiparameter Strategies for Optimizing Supercritical Fluid Chromatography Separations," In Supercritical Fluid Technology: Theoretical and Applied Approaches in Analytical Chemistry; Bright, F. V., McNally, M. E. P., Eds.; American Chemical Society: Washington, D. C., 1992; Vol. 488, pp 304-335.

Crow, J. A.; Foley, J. P. Formic Acid Modified Carbon Dioxide as a Mobile Phase in Capillary Supercritical Fluid Chromatography. J. Microcol. Separ. 1991, 3, 47-57.

Foley, J. P.; Crow, J. A. "Supercritical Fluid Chromatography for the Analysis of Natural Products," In Modern Phytochemical Methods; Fischer, N. H., Isman, M. B., Stafford, H. A., Eds.; Plenum Press: New York, 1991; Vol. 25, pp 113-147.

Crow, J. A.; Foley, J. P. Optimization of Separations in Supercritical Fluid Chromatography Using a Modified Simplex Algorithm and Short Capillary Columns. Anal. Chem. 1990, 62, 378-387.

Crow, J. A.; Foley, J. P. Optimization of Separations Using Short Capillary Columns in Supercritical Fluid Chromatography. HRC-J. High Resolution Chromatogr. 1989, 9, 467-470.

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Environmental/Natural Products

Payne, L. D.; Foley, J. P. "The Presence of Dihydroerythroidines in the Milk of Goats Fed Erythrina Poeppigiana and E. Berteroana Foliage," In Analysis of Antibiotic/Drug Residues in Food Products of Animal Origin; Agarwal, V. K., Ed.; Plenum Press: New York, 1992, pp 211-223.

Payne, L. D.; Foley, J. P. "Gas Chromatography and Mass Spectrometry of Erythrina Alkaloids from the Foliage of Genetic Clones of Three Erythrina Species," In Chromatography and Pharmaceutical Analysis; Ahuja, S., Ed.; American Chemical Society: Washington, D.C., 1992; Vol. 512, pp 85-99.

Tutorials and Critical Reviews

Dorsey, J. G.; Cooper, W. T.; Siles, B. A.; Foley, J. P.; Barth, H. G. Liquid Chromatography: Theory and Methodology. Anal. Chem. 1998, 70, 591R-644R.

Dorsey, J. G.; Cooper, W. T.; Siles, B. A.; Foley, J. P.; Barth, H. G. Liquid Chromatography: Theory and Methodology. Anal. Chem. 1996, 68, 515R-568R.

Arenas, R. V.; Foley, J. P. Polymer-Coated Alumina Columns in Reversed-Phase Liquid Chromatography. Amer. Lab. 1994, 26, 32CC-32JJ.

Dorsey, J. G.; Cooper, W. T.; Wheeler, J. T.; Barth, H. G.; Foley, J. P. Liquid Chromatography: Theory and Methodology. Anal. Chem. 1994, 66, 500R-546R.

Dorsey, J. G.; Foley, J. P.; Cooper, W. T.; Barford, R. A.; Barth, H. G. Liquid Chromatography: Theory and Methodology. Anal. Chem. 1992, 64, 353R-389R.

Dorsey, J. G.; Foley, J. P.; Cooper, W. T.; Barford, R. A.; Barth, H. G. Liquid Chromatography: Theory and Methodology. Anal. Chem. 1990, 62, 324R-356R.

Foley, J. P. The Role of Secondary Chemical Equilibria in Modern Liquid Chromatography. Chromatography Forum 1987, 2, 43-52.

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